Vendaval
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"S.F. General researchers follow strain of drug-resistant bacteria"
Sabin Russell, Chronicle Medical Writer
Tuesday, January 15, 2008
" San Francisco General Hospital researchers have been chasing the rogue strain of drug-resistant staph called USA300 since they first isolated it from a patient specimen seven years ago.
With every turn, the aggressive and persistent bug keeps getting worse.
Now, a new variant of that strain, resistant to six major kinds of antibiotics, is spreading among gay men in San Francisco, Boston, New York and Los Angeles.
City doctors first spotted the original USA300 during tests for patients treated at a walk-in clinic for skin infections in 2001. Since then, they have watched it morph from laboratory curiosity into the dominant form of staph infection in much of the United States.
"It stormed into town and just took over, displacing everything else," said Dr. Chip Chambers, infectious disease chief for the renowned hospital.
At first, USA300 hit the down-and-out: injection-drug users, jail inmates, homeless men and women. Today it is also infecting suburban moms, executives, doctors, athletes and children. It has turned up in tattoo parlors and newborn nurseries.
People with HIV infection seem especially prone to it, but it also strikes patients, gay and straight, who have no previous health problems.
Staph infections are usually treatable but can be lethal. USA300 is as dangerous as they come - it can attack organs throughout the body, forcing doctors to amputate fingers, toes and limbs. Its most disturbing trait, however, is just how easily it gets around.
"USA300 has a tremendous ability to spread," said Francoise Perdreau-Remington, director of the molecular epidemiology lab at San Francisco General, where the strain was first identified. "It has been described in at least 44 states and is now spreading in European countries."
USA300 is one of a dozen distinct varieties of MRSA, or methicillin-resistant Staphylococcus aureus, now circulating. The first MRSA strain, resistant to the penicillin substitute methicillin, was discovered in 1961. It continues to evolve.
More than 200 families of the strain have come and gone since. USA300 is shaping up as the worst of the lot.
The various MRSA families have been gaining strength as a public health menace for years.
MRSA infections used to be confined to hospitalized patients. But in the late 1990s, people began contracting them in community settings - in gyms, jails, schools and even at home. The federal Centers for Disease Control and Prevention calculated last fall that drug-resistant staph was killing 19,000 Americans a year - more than are dying of AIDS."
(Read the rest of the article by clicking on the link below)
http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2008/01/15/MNUKUDB6D.DTL
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< Message edited by Vendaval -- 1/15/2008 11:26:24 PM >
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New strain of drug resistent staph spreading - 
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