RE: Bathtub Genetic Engineering Labs? (Full Version)

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ArticMaestro -> RE: Bathtub Genetic Engineering Labs? (12/27/2008 2:55:13 PM)

There are no common sense regulations.  This is being done in garages and basements, and is no more complicated than a meth lab.  To regulate it would require a total police state/constant observation.   The genie is out of the bottle....




bluepanda -> RE: Bathtub Genetic Engineering Labs? (12/27/2008 10:10:28 PM)

quote:

ask yourself do you really want flesh eating zombies walking about at night? Well do ya???


I'm... thinkin' the answer's "no," right? That'd be my answer. I'm pretty sure of it.




bluepanda -> RE: Bathtub Genetic Engineering Labs? (12/27/2008 10:18:39 PM)

quote:

ORIGINAL: Sanity


I can't help but wonder how difficult might it be for some well-meaning environmentalists or animal rights activists to create something new that could, for example, wipe out the world's wheat or corn production and thereby starve half the people on Earth. Or to create a super cold or flu strain or some other threat capable of eliminating some percentage of our species outright...





You really can't help but wonder that? No shit! Do you think you could help explaining why the fuck, in your worldview, there is any rational reason whatsoever to worry about evironmentalists, of all people, wiping out half the world's wheat production? Wouldn't your time be better spent working yourself into a frothmouthed, glassy-eyed panic over the possibility that stamp collectors will figure out a way to blow up the supervolcano under Yellowstone National Park? Because that makes at least as much, if not tens times more, sense than seriously speculating that animal rights activists would have some motivation to destroy the world's corn production.

Good lord, how do you come up with this shit? Is there some  computer program that just randomly generates them, or do you actually think them up yourself?




bluepanda -> RE: Bathtub Genetic Engineering Labs? (12/27/2008 10:25:45 PM)

quote:

ORIGINAL: Lorr47

quote:

ORIGINAL: MarsBonfire

"Gene hacking" has been around for at least 15 years, maybe more. You can often find genetic splicing equipment on ebay. It's really no more expensive, or time consuming a hobby that running a model Railroad, or getting seriously into computers.

Experimenting with new forms of life "can't hurt?" Hummm... obviously this poster has never read the first few chapters of Steven King's "The Stand"...

The religious nutcases are so friggin worred about experimentation stem cells... too bad they aren't thinking about what the irresponsible "mad scientist" is doing in his garage across town, tinkering with entirely new forms of cellular life, and viruses. If they did, maybe they'd realize how fucked up their priorities really are.



I have never thought it possible to do this sort of thing other than in an expensive lab.  If someone can do it in their garage, someone will.  That is scary.



Scary - you want scary? I got scary for you, and unlike in Sanity's bizarre little fantasy, it has nothing to do with environmentalists. Here's what scary looks like -

quote:


Klebsiella planticola--The Gene-Altered Monster That Almost Got Away The Deadly Genetically Engineered Bacteria that Almost Got Away: A Cautionary Talle Web Note: In the early 1990s a European genetic engineering company was preparing to field test and then commercialize on a major scale a genetically engineered soil bacteria called Klebsiella planticola. The bacteria had been tested--as it turns out in a careless and very unscientific mannner--by scientists working for the biotech industry and was believed to be safe for the environment. Fortunately a team of independent scientists, headed by Dr. Elaine Ingham of Oregon State University, decided to run their own tests on the gene-altered Klebsiella planticola. What they discovered was not only startling, but terrifying-- the biotech industry had created a biological monster--a genetically engineered microorganism that would kill all terrestrial plants. After Ingham's expose, of course the gene-altered Klebsiella planticola was never commercialized. But as Ingham points out, the lack of pre-market safety testing of other genetically altered organisms virtually guarantees that future biological monsters will be released into the environment. Moreover it's not only genetic engineering that poses a mortal threat to our soil ecology, the soil food web, as Ingham calls it. Chemical-intensive agriculture is slowly but surely poisoning our soil and our drinking water as well. Ecological Balance and Biological Integrity Good Intentions and Engineering Organisms that Kill Wheat  by Elaine Ingham, Oregon State University  A genetically engineered Klebsiella-planticola had devastating effects on wheat plants while in the same kind of units, same incubator, the parent bacteria did not result in the death of the wheat plants. Consider that the parent species of bacteria grows in the root systems of every plant that has been assessed for Klebsiella's presence. The bacterium also grows on and decomposes plant litter material. It is a very common soil organism. It is a fairly aggressive soil organism that lives on exudates produced by the roots of every plant that grows in soil. This bacterium was chosen for those very reasons to be engineered: aggressive growth on plant residues....


Well, that was close

That's scary. Yeah, we really need as many people as possible fooling around with this sort of shit in their basements. Let's not stand in the  way of progress, people!




Lorr47 -> RE: Bathtub Genetic Engineering Labs? (12/27/2008 11:40:24 PM)

quote:

That's scary. Yeah, we really need as many people as possible fooling around with this sort of shit in their basements. Let's not stand in the way of progress, people!


But will passing a bunch of statutes stop them?  I doubt it.  Do you have any suggestions?




jlf1961 -> RE: Bathtub Genetic Engineering Labs? (12/27/2008 11:56:31 PM)

Granted, this so called cottage industry needs some sort of supervision, but then, Berkley Breathed made a jab at it way back in Penguin Dreams and Stranger things, pg 59, with the long tailed hamster.




CatdeMedici -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 3:41:18 AM)

quote:

Electricity isn't capable of killing thousands within two weeks if it goes wrong

 
Correct, it can kill thousands in a matter of minutes or hours.

quote:

Haven’t you seen "I am Legend." ask yourself do you really want flesh eating zombies walking about at night? Well do ya???[8|] 
 

Isn't that a bit over dramatic? 




bluepanda -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 5:52:24 AM)

quote:

ORIGINAL: Lorr47

quote:

That's scary. Yeah, we really need as many people as possible fooling around with this sort of shit in their basements. Let's not stand in the way of progress, people!


But will passing a bunch of statutes stop them?  I doubt it.  Do you have any suggestions?



No. No, you're absolutely right, there is no way to put the toothpaste back in the tube. I'm just thinking, it's probably not in anyone's best interests to encourage any more of this sort of thing.

Although at best, I think we're only delaying the inevitable at this point. I find this a lot more frightening than the threat of nuclear proliferation, frankly. A terrorist with a nuke can wipe out a city and cripple a country's economy for several years, a limited nuclear exchange can devastate whole regions of the planet, but only a global nuclear war (something that I think is extremely unlikely) can cause the kind of longterm damage to the planet and to our species that I think genetic engineering can cause. For just one example, feed a few of these papers and articles into your google, and see what comes out the other end, or just google the terms "colony collapse disorder genetic engineering".

Obrycki,J, Losey, J, Taylor,O, Jesee,L. "Transgenic insecticidal corn: Beyond insecticidal toxicity to ecological complexity." Bioscience May 2001/Vol 51 No. 5

Ramirez-Romero, R,  Chaufaux, J and Pham-Delègue, M. "Effects of Cry1Ab protoxin, deltamethrin and imidacloprid on the foraging activity and the learning performances of the honeybee Apis mellifera, a comparative approach" Apidologie 36 (2005) 601-11.

Ricarda A. Steinbrecher, "Risks associated with ingestion of Chardon LL maize, The reversal of N-acetyl-L- glufosinate to the active herbicide L-glufosinate in the gut of animals," Chardon LL Hearing, May 2002, London.

Malone, L and Pham-Delègue, M. "Effects of transgene products on honey bees (Apis mellifera) and bumblebees (Bombus sp.)" Apidologie 32, (2001), 287-304.








Sanity -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 6:28:59 AM)


Wow! Hmm. Sorry if that post skewered some of your nerves blue, but I stand by the examples I used. Not all environmentalists are exactly like Lisa Simpson...

Seriously - you might want to do a little bit of reading, and I would suggest starting here:

http://en.wikipedia.org/wiki/Radical_environmentalism

See especially the notes and references at the bottom of the page.


quote:

ORIGINAL: bluepanda
You really can't help but wonder that? No shit! Do you think you could help explaining why the fuck, in your worldview, there is any rational reason whatsoever to worry about evironmentalists, of all people, wiping out half the world's wheat production? Wouldn't your time be better spent working yourself into a frothmouthed, glassy-eyed panic over the possibility that stamp collectors will figure out a way to blow up the supervolcano under Yellowstone National Park? Because that makes at least as much, if not tens times more, sense than seriously speculating that animal rights activists would have some motivation to destroy the world's corn production.

Good lord, how do you come up with this shit? Is there some  computer program that just randomly generates them, or do you actually think them up yourself?










samboct -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 7:24:43 AM)

For the people who don't want to believe in sensationalist headlines or the "scare of the month club"- let me point out a few things.

1)  Genetic engineering- i.e. gene splicing in a lab or bathtub, (yeah, right) can only use the tools that nature developed.  Humans may be able to speed up the process some, but genetic engineering can't do anything that nature hasn't already done in the past.
2)  Successful examples of human genetic engineering that are "freaks" of nature: Rover, Spot, Fido, etc.  Dogs have the largest size variation within a species of any animal, so much to the point where although a Great Dane and a chihuahua may share similar enough genes to reproduce successfully, in practice, it's a bit of a long shot.  Note that most breeds were established long before the structure of DNA was known.  Most of the foods we eat are genetically engineered whether plant or animal protein.  Some wildlife such as fish, deer or pinecones (anybody remember Eull Gibbons?) are an exception.
3)  I chuckle at the arrogance that suggests that humans know enough to devise some type of plant/animal/bacteria/virus that's going to wipe us all out.  This shows an incredible lack of appreciation for nature's evolutionary processes which are really rather robust.  Face it- if everything stayed the same, we'd still be a bunch of slime in a pool on a rock.  OK, some of us don't seem to have evolved very far.  There are two major types of genetic mutations- intra species which are the most common, and interspecies (bacterial genes into a plant genome as an example) which I think some of the sequencing has shown may be a bit more common than first realized.  This is where manipulation of DNA directly comes into play, since classical genetic engineering (breeding) kind of runs into a roadblock.  But nature's figured out how to do it.
4)  Nature has devised some absolutely brilliant killing machines.  I work in nanotechnology and some nanoparticles are incredibly dangerous.  I can give you an example of nanoparticle thats about 75 nm long, carries its own programming to build self replicating factories using human cells as starting materials, can hide from the bodies immune system indefinitely, can lie dormant for over a decade, and when it breaks out, is nearly invariably fatal.  Any guesses?  How about HIV- the virus that causes AIDS?  Do we really need to go through the list of nature's killing machines including the bacterias responsible for black plague, TB, smallpox, cholera etc.  Or viruses responsible for things like dengue, Japanese encephalitis, West Nile, etc.?  We're not even close to understanding how to design something like these viruses.  The suggestion to try and ban genetic engineering is on par with trying to ban fireworks because it might lead to spaceships one day that bring the Borg down upon us.... 
5)  We can all do genetic engineering in a bathtub.  Well, sorry, I forgot about some of the folks on this board.  Anyhow, all that's needed is a fertile human female and a working male reproductive system having intercourse in a bathtub.  Voila- random genes being thrown together- who knows what the result will be?  My money is on a normal baby, unless of course you take two people living on top of a toxic waste dump in New Jersey......


Sam




Raechard -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 7:36:12 AM)

quote:

ORIGINAL: CatdeMedici
Correct, it can kill thousands in a matter of minutes or hours.

Please give an example of that, it must of passed me by that great electricity plague of 19##
quote:


Isn't that a bit over dramatic?

Yeah, I wasn't being serious, sorry for the confusion.




Sanity -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 7:49:51 AM)


You're confusing "Animal Husbandry" with "Genetic Engineering".

The two are distinctly separate fields.

And, sorry you don't get the intended humor of the tongue-in-cheek thread title, but hey - I can't please everyone.

Finally, of course there are hazards associated with gene splicing, I'm not even going to argue the obvious with you - and as far as whether or not amateurs are doing it is concerned, I simply  refer you to the article linked to in the OP. 


quote:

ORIGINAL: samboct

For the people who don't want to believe in sensationalist headlines or the "scare of the month club"- let me point out a few things.

1)  Genetic engineering- i.e. gene splicing in a lab or bathtub, (yeah, right) can only use the tools that nature developed.  Humans may be able to speed up the process some, but genetic engineering can't do anything that nature hasn't already done in the past.
2)  Successful examples of human genetic engineering that are "freaks" of nature: Rover, Spot, Fido, etc.  Dogs have the largest size variation within a species of any animal, so much to the point where although a Great Dane and a chihuahua may share similar enough genes to reproduce successfully, in practice, it's a bit of a long shot.  Note that most breeds were established long before the structure of DNA was known.  Most of the foods we eat are genetically engineered whether plant or animal protein.  Some wildlife such as fish, deer or pinecones (anybody remember Eull Gibbons?) are an exception.
3)  I chuckle at the arrogance that suggests that humans know enough to devise some type of plant/animal/bacteria/virus that's going to wipe us all out.  This shows an incredible lack of appreciation for nature's evolutionary processes which are really rather robust.  Face it- if everything stayed the same, we'd still be a bunch of slime in a pool on a rock.  OK, some of us don't seem to have evolved very far.  There are two major types of genetic mutations- intra species which are the most common, and interspecies (bacterial genes into a plant genome as an example) which I think some of the sequencing has shown may be a bit more common than first realized.  This is where manipulation of DNA directly comes into play, since classical genetic engineering (breeding) kind of runs into a roadblock.  But nature's figured out how to do it.
4)  Nature has devised some absolutely brilliant killing machines.  I work in nanotechnology and some nanoparticles are incredibly dangerous.  I can give you an example of nanoparticle thats about 75 nm long, carries its own programming to build self replicating factories using human cells as starting materials, can hide from the bodies immune system indefinitely, can lie dormant for over a decade, and when it breaks out, is nearly invariably fatal.  Any guesses?  How about HIV- the virus that causes AIDS?  Do we really need to go through the list of nature's killing machines including the bacterias responsible for black plague, TB, smallpox, cholera etc.  Or viruses responsible for things like dengue, Japanese encephalitis, West Nile, etc.?  We're not even close to understanding how to design something like these viruses.  The suggestion to try and ban genetic engineering is on par with trying to ban fireworks because it might lead to spaceships one day that bring the Borg down upon us.... 
5)  We can all do genetic engineering in a bathtub.  Well, sorry, I forgot about some of the folks on this board.  Anyhow, all that's needed is a fertile human female and a working male reproductive system having intercourse in a bathtub.  Voila- random genes being thrown together- who knows what the result will be?  My money is on a normal baby, unless of course you take two people living on top of a toxic waste dump in New Jersey......


Sam




ThatDaveGuy69 -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 7:50:38 AM)

Well put, Sam :)
While it is possible to make many of the tools needed for this type of work, I feel reasonably safe that you can't purchase a Little Geneticist Fun Time Sampler full of deadly bacteria down at your local Walmart.  These people are playing with yogurt and squid - not e-bola and TB!  And while they are teaching themselves how to mix & match protien chains to alter a few benign bodies, they are lightyears away from creating a super-bug capable of wiping out wheat or corn production.  Yeah, the whole idea gives me a moments pause.  But then I go back to worrying about how to keep my house now that the foreclosure is nearly final.  Perspective, folks.  We have more to fear from a so-called "rogue nations" buying up genetic and/or nuclear hardware and talent to use it than we do from the home-brew crowd.

~Dave
I thought that getting a new keyboard would lead to fewer typos.  I guess not...






samboct -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 8:05:51 AM)

Sanity

Nope-I'm not confusing animal husbandry with genetic engineering- animal husbandry is genetic engineering.  The tools are a bit different- in one case we have a complete genetic factory able to produce offspring, and with DNA manipulation directly, there need to be some more external inputs.  But in both cases we're manipulating genetic material to get a desired result.

In terms of the original article- my point is that the gene splicing they're waving the red flag about actually takes place all over the world in an uncontrolled fashion on a constant basis.  A less alarming article doesn't sell newspapers.  The author is either exploiting the audiences' naivete, or more likely, is just that ignorant themselves.

And I got your tongue in cheek humor- guess you didn't get mine....


Dave

I'm not too worried about superbugs destroying everything- nature's viruses and bacterias will likely teach us a lesson far sooner than a rogue nation with Acme spawned genetic monsters.  (Wile E. Coyote- SUPER Genius....)  The spread of dengue, especially aided by global warming, is much more of a realistic threat.  As far as I can tell, superbugs are not possible.  Consider- any bacteria that's going to spew out lots of nasty toxins such as anthrax can only spew out so much.  When you try to make it barf out more, the bug gets too delicate and dies with a harsh look.  And most of the bio toxins are actually rather short lived- they're relatively large molecules and get wiped out by changes in pH, UV, etc.  The only weapon of mass destruction I worry about is the one with a proven track record- the nuclear bomb.

Sam




Owner59 -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 3:40:31 PM)

Good lord, how do you come up with this shit?


The best question yet.




awmslave -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 6:25:48 PM)

To be correct genetic engeneering and breeding are not synonomous. Genetic engeneering refers to direct manipulation of genes while breeding to non-direct. To my best knowledge the selection is the most important tool of breeding while genetic engeneering uses isolated genes that are modified and then directly inserted using different vectors.




Sanity -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 7:47:05 PM)


Yeah, thank you, awmslave. Obviously there are vast differences between goat herders and genetic engineers (though I don't always feel a need or have enough patience to try to explain the obvious).








samboct -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 8:29:24 PM)

Yes- goat herders can smell better......

To anyone who works in a gene splicing facility- sorry- couldn't resist the dig.




samboct -> RE: Bathtub Genetic Engineering Labs? (12/28/2008 8:36:51 PM)

Hi awmslave

Yah- you are correct- genetic engineering and selective breeding are not synonyms.  But come on, they are both tools for genetic manipulation.  Around 20 years ago, one of the comments I heard on a talk about gene insertion (which was where the comment that nature doesn't let us do anything that she hasn't done before- it just speeds up the process) was that trying to figure out which genes to manipulate in livestock to increase growth rates wasn't getting very far.  Basically, the selective breeding had done quite well, and there really weren't that many tweaks that the biologists could come up with.

Sam




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