Rule -> RE: Jew Hitler a Rothschild? ?? huh? (1/20/2010 11:21:41 AM)
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ORIGINAL: DomKen Why would I respond to your questions when they have no basis in reality? What makes you the arbiter of what reality is? Are you a supergenius? quote:
ORIGINAL: DomKen For instance: quote:
1 in 4 is a weak selection? Are you quite sure about that? Especially as it concerns not 1 in 4 of the deleterious alleles, but two in four (= half). Anything with a higher frequency than 1 in a thousand is an extremely strong selection! 1 in 2 is a humongously immense gargantuan gigantic selection. Who are you trying to fool? Is nonsense. DomKen, I here asked two simple questions: 1. 1 in 4 is a weak selection? 2. Who are you trying to fool? What is so difficult about answering those questions? For lack of an answer, I can only surmise that you do not have a clue what constitutes weak and what constitutes strong selection. I even tried to help you by giving away the answer: "Anything with a higher frequency than 1 in a thousand is an extremely strong selection!" In fact, in the evolution algorithm all selection frequencies, however infinitesimal, are additive and count. If there is a mutation that confers a 1 in one billion chance of being beneficial or deleterious, it will be selected for or against. All it requires are one billion of bacteria with such a mutation for the effect to present itself in one of them. (In truth in such cases other factors, like genetic drift, will be far more dominant, but nevertheless the infinitesimal selection frequency does count.) quote:
ORIGINAL: DomKen Just to illustrate the problem, the homozygous offspring of two heterozygous parents is always a 1 in 4 chance never 1 in 2. The 1 in 2 chance is for a heterozygous offspring. That is precisely what I earlier said in my stacks of cards post. Who are you to say that I do not understand the basics of population genetics? Obviously I do, since you are merely repeating what I said earlier. You would do better to criticize your own reading comprehension rather than my grasp of population genetics, not so? As an example of your failure to comprehend what I wrote I quote myself: "Especially as it concerns not 1 in 4 of the deleterious alleles, but two in four (= half)". I am here not talking about the frequency of offspring homozygous for a deleterious (lethal) recessive mutation, but about the proportion of deleterious alleles removed on average from the gene pool of the progeny of two heterozygous parents. If a is the recessive homozygously lethal allele, then Aa x Aa will result in offspring with the combinations AA, Aa, Aa and aa. Total number of A alleles in the offspring = 4. Total number of a alleles in the offspring = 4. Death of the homozygously lethal recessive offspring removes two a alleles from the gene pool of the offspring. 2/4 means half of the recessive lethal genes are removed from the gene pool by marriages of heterozygous individuals. Do I need to give you an abacus? quote:
ORIGINAL: DomKen In almost all cases being heterozygous for a lethal recessive is completely neutral as far as selection is concerned." Quite: as far as natural selection is concerned, I stipulate. quote:
ORIGINAL: DomKen As a matter of fact everyone reading this is likely heterozygous for several lethal genetic diseases and are completely unaffected and unaware." Nevertheless in an earlier post you said something far more true and far more percipient: "half their offspring will continue to silently, or nearly silently, carry the recessive". What is it, DomKen: silently or nearly silently? Make up your mind. I will give you a hint: natural selection is not the only form of selection and in fact is insignificant compared to a far more powerful and far more discerning type of selection. That you are not aware of the deleterious mutations that you yourself carry, does not mean that others are also not aware of them. quote:
ORIGINAL: DomKen Now since one half of the offspring of a heterozygous couples offspring will heterozygously carry the gene and only another 1 in 4 will fail to reproduce it is actually nearly impossible for selection to remove the lethal recessive once it is established in the gene pool. Here you pay the price for not confirming that my every statement is true. I ask you again to confirm this my statement: "Spontaneous deleterious mutations occur in all populations at the same frequency". (I am quite aware that arguments that disagree with that my statement may be raised, like spiritual and environmental and genetic arguments, but I propose to disregard such complications for the sake of a clear discussion.) Therefore: Do you agree that new deleterious mutations occur in the same frequencies in populations that circumcise the penis of their male offspring and in the indigenous European Christian population? (If you disagree, then I will be most interested in learning from you why you think that the frequencies differ.) If you do agree, then please do explain why indigenous European Christian populations are so much better at removing deleterious mutations from their gene pool that the frequency of lethal inherited diseases among them is six times lower than among Jews and Muslims, despite not using the Jewish method of inbreeding in order to remove half of the deleterious alleles from their gene pool. I know why this is, but I am most interested in your answer. I will give you another hint: obviously, it is not impossible for selection to efficiently remove deleterious alleles from the gene pool. It is only impossible for Jewish populations to have selection do so. Why? quote:
ORIGINAL: DomKen Otherwise the only way to completely remove a lethal recessive from the gene pool is if the heterozygous state is also selected against and that is very rare, as in only a handful of known lethal recessives out of the thousands known to exist. Nevertheless the indigenous Euopean Christian population manages to do so very well, and not only the lethal deleterious mutations. The data support that. Why? quote:
ORIGINAL: DomKen This is the case because in general our body can get on quite well with only making half as much of some protein. The cells involved simply spend more time making that protein which in most cases isn't noticeable. That does not mean that it does not count, nor does it mean that the deleterious proteins are not made and do not have some effect. (Like wasting energy and resources making a deleterious protein.) Edited to add: DomKen, I know that you have made quite an effort to become knowledgeable about these matters. I admire and respect you for that. However, merely knowing something does not a scientist make. In fact there are lots of scientists - 96 per cent - who have no clue who know lots of things and are quite smart, but who cannot discover something new even if it stood on their toes and hurt. Nor do I am very much impressed by the other four per cent.
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