RE: Jew Hitler a Rothschild? ?? huh? (Full Version)

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LadyEllen -> RE: Jew Hitler a Rothschild? ?? huh? (1/21/2010 5:19:37 PM)

Yeah? well you goyim are all knobs

James T Kirk




Rule -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 3:32:52 AM)

quote:

ORIGINAL: DomKen
Lethal recessive mutations do not occur at a steady fixed rate. They are exceedingly rare. The overwhelming majority of mutations are completely or nearly completely neutral. For a mutation to be a lethal recessive basically requires that that mutation render the protein produced ineffective at doing its job. Most amino acids that comprise a protein are simply filler to produce an enzyme of the correct size and shape. Substituting one for another will have either no effect or very minor effect. it is generally only possible to break a protein at one end or the other so lethal mutations are only possible in those very tiny regions of the genome and since mutation of any kind is a very rare event it simply does not follow that the rate can be predicted in the way you postulate.

It is a model for theoretical purposes, and as such it does not need to be realistic.

Are you now asserting that new lethal mutations in larger populations occur at another frequency than in smaller populations?

quote:

ORIGINAL: DomKen
Furthermore you still fail to understand the flaw in your example. if the small population of 10 has one new, lethal recessive mutation in each generation then that means that 10 percent of that population has that specific lethal mutation and it will likely be expressed quite quickly. Your other population postulates 10 different lethal mutations in a generation of 100 which of course means that each lethal is only present in 1% of the population and it is much less likely to be expressed.

That is what my model shows: same absolute number of homozygotic lethal recessive and absence of heterozygotic lethal recessive, but at relatively ten times lower frequency. Why are you always repeating me?

I also notice that as usual you have not answered any of my questions.

I will have to think a bit more about the disparity between smaller and larger populations; it certainly is interesting.




DomKen -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 8:44:04 AM)


quote:

ORIGINAL: Rule

quote:

ORIGINAL: DomKen
Lethal recessive mutations do not occur at a steady fixed rate. They are exceedingly rare. The overwhelming majority of mutations are completely or nearly completely neutral. For a mutation to be a lethal recessive basically requires that that mutation render the protein produced ineffective at doing its job. Most amino acids that comprise a protein are simply filler to produce an enzyme of the correct size and shape. Substituting one for another will have either no effect or very minor effect. it is generally only possible to break a protein at one end or the other so lethal mutations are only possible in those very tiny regions of the genome and since mutation of any kind is a very rare event it simply does not follow that the rate can be predicted in the way you postulate.

It is a model for theoretical purposes, and as such it does not need to be realistic.

Are you now asserting that new lethal mutations in larger populations occur at another frequency than in smaller populations?

I'm telling you that there is no predictable rate of new lethal mutations.

quote:

quote:

ORIGINAL: DomKen
Furthermore you still fail to understand the flaw in your example. if the small population of 10 has one new, lethal recessive mutation in each generation then that means that 10 percent of that population has that specific lethal mutation and it will likely be expressed quite quickly. Your other population postulates 10 different lethal mutations in a generation of 100 which of course means that each lethal is only present in 1% of the population and it is much less likely to be expressed.

That is what my model shows: same absolute number of homozygotic lethal recessive and absence of heterozygotic lethal recessive, but at relatively ten times lower frequency. Why are you always repeating me?

I also notice that as usual you have not answered any of my questions.

I will have to think a bit more about the disparity between smaller and larger populations; it certainly is interesting.

You still fail to grasp the signifigance in regards to your claims that close breeding does not result in increased instances of genetic disease.




Rule -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 10:37:11 AM)

quote:

ORIGINAL: DomKen
I'm telling you that there is no predictable rate of new lethal mutations.

There isn't? [:-] [8|]

quote:

ORIGINAL: DomKen
You still fail to grasp the significance in regards to your claims that close breeding does not result in increased instances of genetic disease.

If only I knew what you were referring to, perhaps I might grasp that significance.




mnottertail -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 10:41:23 AM)

six fingered amish, thats one thing hes talking about




DomKen -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 10:52:58 AM)

quote:

ORIGINAL: Rule

quote:

ORIGINAL: DomKen
I'm telling you that there is no predictable rate of new lethal mutations.

There isn't? [:-] [8|]

What is the rate then? The rate of generic mutation is well known so you should be able to provide the other rate if it is possible to calculate. It isn't so you can't.

quote:

quote:

ORIGINAL: DomKen
You still fail to grasp the significance in regards to your claims that close breeding does not result in increased instances of genetic disease.

If only I knew what you were referring to, perhaps I might grasp that significance.


You've repeatedly claimed that close breeding doesn't result in more frequent expression of genetic disease. You've also expressed the belief that close breeding will remove lethal recessives from the gene pool. Both are incorrect as any actual population genetics math will show.






Rule -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 11:25:52 AM)

quote:

ORIGINAL: DomKen
quote:

ORIGINAL: Rule
quote:

ORIGINAL: DomKen
I'm telling you that there is no predictable rate of new lethal mutations.

There isn't? [:-] [8|]

What is the rate then? The rate of generic mutation is well known so you should be able to provide the other rate if it is possible to calculate. It isn't so you can't.

Supply me with the figures and I will calculate the rate.
Of course there is a rate. There is a rate for everything. That there is a rate is not an issue.

quote:

ORIGINAL: DomKen
You've repeatedly claimed that close breeding doesn't result in more frequent expression of genetic disease. You've also expressed the belief that close breeding will remove lethal recessives from the gene pool.

Please supply quotes of these my statements, including post numbers if necessary.

quote:

ORIGINAL: DomKen
Both are incorrect as any actual population genetics math will show.

I have done the genetics calculations in this thread. Perhaps you have missed them?




Moonhead -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 1:41:49 PM)


quote:

ORIGINAL: mnottertail

six fingered amish, thats one thing hes talking about

It's such a pity about that whole luddism thing: they'd make brilliant typists...




mnottertail -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 1:44:19 PM)

Now you know why there are not 10 eggs in a carton. They never knew there was another finger counting method.

George Bontreger




Moonhead -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 1:46:43 PM)

They could work in base 24 if they take their shoes off as well.




mnottertail -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 1:54:43 PM)

I dont think they will go past the 'hex' thing, a supersitious bunch of luddites they are.

Around here they use chainsaws to cut the beads off tractor tires and rivet the treads on the steel wheelers so they can move across federal, state, and county highways.

They missed out on the Bill Cosby album 'Why is there Air?' because it was electronical.

Ron




Moonhead -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 2:55:05 PM)


quote:

ORIGINAL: mnottertail
a supersitious bunch of luddites they are

Yoda?




thornhappy -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 4:48:05 PM)

quote:

ORIGINAL: mnottertail

six fingered amish, thats one thing hes talking about

Maple syrup urine disease (descriptive, eh?)




DomKen -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 5:08:34 PM)


quote:

ORIGINAL: Rule

quote:

ORIGINAL: DomKen
quote:

ORIGINAL: Rule
quote:

ORIGINAL: DomKen
I'm telling you that there is no predictable rate of new lethal mutations.

There isn't? [:-] [8|]

What is the rate then? The rate of generic mutation is well known so you should be able to provide the other rate if it is possible to calculate. It isn't so you can't.

Supply me with the figures and I will calculate the rate.
Of course there is a rate. There is a rate for everything. That there is a rate is not an issue.

Of course there is no rate since there is no way to even predict which mutations are lethal. The rate of point mutations is about 2 x 10^-9 per site per year. but that doesn't tell you if the mutation occured in a gene, whether or not it was a lethal recessive etc.. Even knowing what percentage of the genome is actually genes doesn't help since you simply cannot predict which mutations will be lethal.

quote:

quote:

ORIGINAL: DomKen
You've repeatedly claimed that close breeding doesn't result in more frequent expression of genetic disease. You've also expressed the belief that close breeding will remove lethal recessives from the gene pool.

Please supply quotes of these my statements, including post numbers if necessary.

post 106
quote:

This is where you go wrong and put the cart before the horse. Merely apply the evolution algorithm: any behavior that causes a disadvantageous reproductive effect, will be selected against by natural selection. The fact that these populations that are cursed with deleterious mutations are inbreeding, indicates conclusively that by not doing so they would be even worse off. They derive a huge reproductive benefit from inbreeding and it is quite obvious what that benefit is: the elimination of half of the deleterious alleles from their gene pool. Nevertheless that does not suffice to cleanse their gene pool, as compared to European Christian populations that do not circumcise their male offspring.


Post 108 in its entirety.

post 117
quote:

If you do agree, then please do explain why indigenous European Christian populations are so much better at removing deleterious mutations from their gene pool that the frequency of lethal inherited diseases among them is six times lower than among Jews and Muslims, despite not using the Jewish method of inbreeding in order to remove half of the deleterious alleles from their gene pool. I know why this is, but I am most interested in your answer.


post 119 in its entirety

post 140 in its entirety

post 145 in its entirety




xBullx -> RE: Jew Hitler a Rothschild? ?? huh? (1/25/2010 5:26:28 PM)


quote:

ORIGINAL: mnottertail

six fingered amish, thats one thing hes talking about


Would the above reference incorporate 5 fingers and a single thumb or four fingers and dual thumbs? If the thumbs were paired would the pair of thumbs be co-mingled or opposing and if on either side of the hand one might want to fantaize about the potential for exceptional episodes of fantasic masterbation therefore risking increased instances of singular sexual encounters thereby risking the possibility of human extinction... Or at least mass blindness.




Rule -> RE: Jew Hitler a Rothschild? ?? huh? (1/26/2010 5:31:30 AM)

quote:

ORIGINAL: DomKen
Of course there is no rate since there is no way to even predict which mutations are lethal. The rate of point mutations is about 2 x 10^-9 per site per year. but that doesn't tell you if the mutation occured in a gene, whether or not it was a lethal recessive etc.. Even knowing what percentage of the genome is actually genes doesn't help since you simply cannot predict which mutations will be lethal.

I quote: "the total number of mutations per offspring per generation is at least 175. If the functional genome percentage was actually 50% (instead of just 2%), the likely detrimental mutation rate (Ud) would be well over 30 instead of the usual estimates of ~3 noted above. This would increase the reproductive rate needed to avoid genomic decay from ~20 offspring per woman per generation to well over 10 trillion offspring per woman per generation - obviously an impossible hurdle to overcome".

(I do note that no scientific article should be trusted implicitly. Nevertheless, the book quoted above appears to be quite knowledgeable. I recommend reading the entire chapter "The Detrimental Mutation Rate and the Genetic Deterioration of Mankind", which is what I am doing now.)

Unbeknownst to me there appears to be a quite active field of genetics that studies mutation rates and the rate of deleterious mutations in humans. I am quite interested. These researchers are way beyond my feeble attempts at genetics.

Edited to add: The quoted part does not appear to be limited to recessive lethals only.




kittinSol -> RE: Jew Hitler a Rothschild? ?? huh? (1/26/2010 5:39:14 AM)

So, Hitler was Jewish, therefore he must have had a circumcised penis, which is why he was so CRAZY! 

It all makes so much sense.




xBullx -> RE: Jew Hitler a Rothschild? ?? huh? (1/26/2010 5:42:01 AM)

That makes you crazy?

quote:

ORIGINAL: kittinSol

So, Hitler was Jewish, therefore he must have had a circumcised penis, which is why he was so CRAZY! 

It all makes so much sense.





kittinSol -> RE: Jew Hitler a Rothschild? ?? huh? (1/26/2010 5:44:13 AM)

No, because I do not have a circumcised penis [8D] . I bask in my glorious feminine superiority: I am so far removed from these ridiculous penile notions.




xBullx -> RE: Jew Hitler a Rothschild? ?? huh? (1/26/2010 5:49:48 AM)

uhmmmmm, ok....

you just hold that thought and I may get back to you

quote:

ORIGINAL: kittinSol

No, because I do not have a circumcised penis [8D] . I bask in my glorious feminine superiority: I am so far removed from these ridiculous penile notions.





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