tazzygirl
Posts: 37833
Joined: 10/12/2007
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quote:
If muscles etc. were the source of the problem then why do SNRI's work so well for so many?
Pain causes depression. Not all fibro patients are depressed. Not all fibro patients respond to SNRI's. But imagine the level of depression after dealing with the pain for years before most people are diagnosed. Of course SNRI's are going to be beneficial.
Approximately 80 percent of the human body's total serotonin is located in the enterochromaffin cells in the gut, where it is used to regulate intestinal movements.[1][2] The remainder is synthesized in serotonergic neurons in the CNS where it has various functions. These include the regulation of mood, appetite, sleep, as well as muscle contraction. Serotonin also has some cognitive functions, including in memory and learning. Modulation of serotonin at synapses is thought to be a major action of several classes of pharmacological antidepressants
The bolded are two major issudes for fibro patients.
As a stress hormone, norepinephrine affects parts of the brain, such as the amygdala, where attention and responses are controlled.[4] Along with epinephrine, norepinephrine also underlies the fight-or-flight response, directly increasing heart rate, triggering the release of glucose from energy stores, and increasing blood flow to skeletal muscle. It increases the brain's oxygen supply.[5] Norepinephrine can also suppress neuroinflammation when released diffusely in the brain from the locus coeruleus.[6]
Norepinephrine gives you that "fight of flight" feeling... the one that can block any feeling of pain until it comes back down.
The combination would certainly block pain, but would it do anything to actually treat it?
A large percentage of fibromyalgia patients suffer from unrefreshing or disturbed sleep. You may have difficulty falling asleep or you may wake up several times during the night. Or perhaps you feel completely exhausted even though you’ve gotten eight full hours of sleep. These sleep disorders can contribute to the pain of fibromyalgia, increasing muscle stiffness, exacerbating fatigue, and heightening depression. But sleep disorders may not just be a symptom of fibromyalgia – instead, they may actually be the cause of the syndrome.
Deep Sleep
Deep sleep is one of the most important stages of your sleeping cycle. Classified as Stage Four of the sleep cycle, it is during deep sleep that your muscles are repaired, your tissue is grown, and your energy is replenished. Without proper deep sleep, you would not be able to function at normal capacity.
Fibromyalgia patients appear to undergo less deep sleep than healthy men and women. As a result, they suffer from a variety of symptoms including:
increased muscle pain
mood disorders, like depression
fatigue
fibrofog
Somatemedin-C
During deep sleep, a hormone known as somatomedin-C is released by your body. Somatomedin-C is responsible for ensuring proper nerve and muscle health. 90% of somatomedin-C is released during Stage Four deep sleep. Because fibromyalgia patients do not get enough deep sleep, they have much lower levels of somatomedin-C. This could explain the extreme muscle and nerve pain that fibromyalgia patients suffer from.
http://www.fibromyalgia-symptoms.org/fibromyalgia_sd.html
This is what my neurologist was getting at years ago.
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RE: Over stimulation with pain, causes Fibro? - 
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