RE: Sorting Adam Lanza's Genome For Clues (Full Version)

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DomKen -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 4:12:19 PM)

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

Autism is definitely not genetic but behavior is to some degree.


No one knows what causes autism but scientists have identified up to 40% as being inherited with a genetic underlying cause.

Genetics influences behaviour as does experience, environment, diet, parental relationships etc etc. To isolate out genetics as a sole cause of behaviour as though genetics can predict bahaviour is a 21st century equivalent of 19th century phrenology.

That's out of date or best simplistic. There does appear to be an inherited aspect, escpecially when the father is older, but it looks like it is epigenetic and not strictly genetic.




DomKen -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 4:16:37 PM)

quote:

ORIGINAL: meatcleaver

quote:

ORIGINAL: vincentML

Your reasoning is absolutist and ass backwards. Pure nonsense. Not all violent offenders are psychopathic and not all psychopaths are violent offenders, for example.

It is more logical to say that if a person is so tortured by a mental disorder that he becomes a spree killer it is reasonable to identify others with a similar mental disorder for treatment, and it is reasonable to seek a more efficacious regimen.



You have your head up your ass when you consider 30% of the population will suffer mental illness in their life time. Let me repeat 30% That many makes mental illness normal and mass murder is not normal so where is the correlation?

You are lumping all mental illness into one pile. Most mental illness does not result in violence and most mental illness does not have a clear cut physical component. Until we study Lanza we have no idea whether he had a genetically caused mental illness or not.

In science acquiring more data is always a good thing and in this case even if sequencing Lanaza's genome reveals nothing it will still advance cience.




IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 4:19:44 PM)


quote:

ORIGINAL: DomKen

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

Autism is definitely not genetic but behavior is to some degree.


No one knows what causes autism but scientists have identified up to 40% as being inherited with a genetic underlying cause.

Genetics influences behaviour as does experience, environment, diet, parental relationships etc etc. To isolate out genetics as a sole cause of behaviour as though genetics can predict bahaviour is a 21st century equivalent of 19th century phrenology.

That's out of date or best simplistic. There does appear to be an inherited aspect, escpecially when the father is older, but it looks like it is epigenetic and not strictly genetic.


How many links do you want?

I could post another thirty.




IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 4:24:14 PM)


quote:

ORIGINAL: DomKen

You are lumping all mental illness into one pile. Most mental illness does not result in violence and most mental illness does not have a clear cut physical component.


Isn't that his point?

quote:

ORIGINAL: DomKen
Until we study Lanza we have no idea whether he had a genetically caused mental illness or not.


It is too late he is dead. I think that was part of meat's point, he's dead and no matter how many genetic conditions he has, it will prove nothing about his mental health. But I am sure meatcleaver can speak for himself.

However, I did mention earlier, this fixation of genes is 21st century equivalent of 19th century prenology. It's voodoo.





DomKen -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 4:29:00 PM)

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

Autism is definitely not genetic but behavior is to some degree.


No one knows what causes autism but scientists have identified up to 40% as being inherited with a genetic underlying cause.

Genetics influences behaviour as does experience, environment, diet, parental relationships etc etc. To isolate out genetics as a sole cause of behaviour as though genetics can predict bahaviour is a 21st century equivalent of 19th century phrenology.

That's out of date or best simplistic. There does appear to be an inherited aspect, escpecially when the father is older, but it looks like it is epigenetic and not strictly genetic.


How many links do you want?

I could post another thirty.

And those would all be from before about 2010. New science suggests the inheritable factor is not genetic but epigenetic. The studies showing that a fathers younger offspring are very likely to have autism but those fathered after 40 have an increased chance showed that it was not strictly genetic but some other sort of inheritance with the most likely one being epigentic.




DomKen -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 4:31:48 PM)

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

You are lumping all mental illness into one pile. Most mental illness does not result in violence and most mental illness does not have a clear cut physical component.


Isn't that his point?

His point seems to be that we shouldn't learn anything from this man.

quote:

ORIGINAL: DomKen
Until we study Lanza we have no idea whether he had a genetically caused mental illness or not.


It is too late he is dead. I think that was part of meat's point, he's dead and no matter how many genetic conditions he has, it will prove nothing about his mental health. But I am sure meatcleaver can speak for himself.

However, I did mention earlier, this fixation of genes is 21st century equivalent of 19th century prenology. It's voodoo.

No, it is not. While genetics does not control every aspect of your life it does influence everything you are and do. And the more we know about the limits of genetic's effect on our behaviour the more we'll also learn about what role environment has.

More information is always better than less.




IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 4:35:45 PM)


quote:

ORIGINAL: DomKen

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

Autism is definitely not genetic but behavior is to some degree.


No one knows what causes autism but scientists have identified up to 40% as being inherited with a genetic underlying cause.

Genetics influences behaviour as does experience, environment, diet, parental relationships etc etc. To isolate out genetics as a sole cause of behaviour as though genetics can predict bahaviour is a 21st century equivalent of 19th century phrenology.

That's out of date or best simplistic. There does appear to be an inherited aspect, escpecially when the father is older, but it looks like it is epigenetic and not strictly genetic.


How many links do you want?

I could post another thirty.

And those would all be from before about 2010. New science suggests the inheritable factor is not genetic but epigenetic. The studies showing that a fathers younger offspring are very likely to have autism but those fathered after 40 have an increased chance showed that it was not strictly genetic but some other sort of inheritance with the most likely one being epigentic.


You are involved in sophistry. Whether someone is born with a black skin or a white skin is epigenetic and not genetic. Many heritable conditions which we consider genetically inherited are epigeneitc. I suspect this is what meat was getting at when he claimed researching gense without environment and experience is pointless.




IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 4:39:30 PM)


quote:

ORIGINAL: DomKen

His point seems to be that we shouldn't learn anything from this man.


From my reading of his posts, he was saying nothing can be learnt from Lanza that can't be learnt elsewhere. Something completely different to what you are claiming.

quote:

ORIGINAL: DomKen

No, it is not. While genetics does not control every aspect of your life it does influence everything you are and do. And the more we know about the limits of genetic's effect on our behaviour the more we'll also learn about what role environment has.

More information is always better than less.


Influence is not cause. To have any value one would have to research Lanza's upbringing, parental relationships, diet and everything else that has been listed by others.




DomKen -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 5:03:59 PM)

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

His point seems to be that we shouldn't learn anything from this man.


From my reading of his posts, he was saying nothing can be learnt from Lanza that can't be learnt elsewhere. Something completely different to what you are claiming.

Until we look how would we know?




jlf1961 -> RE: Sorting Adam Lanza's Genome For Clues (1/4/2013 5:31:05 PM)

The only way they could find anything connecting genetics to mass killers would be if they had the genetic material from every mass killer since Columbine. If there were found a marker that was the same in all cases there would be something to consider, but they would then have to compare that to a larger control group.

Personally, I still say that it is in the genetic make up of the majority of humans to kill other humans. A select few examples, like Ghandi, are an evolutionary anomaly, or an example of the next phase in human development.




IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 1:39:39 AM)


quote:

ORIGINAL: DomKen

Until we look how would we know?



I think you are misrepresenting meat but he can defend himself.

However, you brought up epigenetics which illustrates that genetics is not simple which I think you claimed. What epigenetics means is that physical environment (chemicals in the milieu), emotional environment (chemicals levels produced by the body as in stress) etc are very important because chemicals appear to act as switches and relays. In that sense you are proving meat's point, without studying Lanza's background in all aspect, studying his genes is rather pointless in regard to his specific behaviour.

With that I'm out of here because I don't want to get sucked into arguing about pedantic and disingenuous points just for scoring's sake.




IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 1:42:53 AM)


quote:

ORIGINAL: jlf1961

Personally, I still say that it is in the genetic make up of the majority of humans to kill other humans. A select few examples, like Ghandi, are an evolutionary anomaly, or an example of the next phase in human development.


Whether it is genetic or not, who knows but we have the whole of human history which proves humans aren't averse to killing other humans under the right conditions and out of the sheer hell of it.




DomKen -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 8:44:52 AM)

quote:

ORIGINAL: IgorsHand


However, you brought up epigenetics which illustrates that genetics is not simple which I think you claimed.

Epigenetics is not genetics. The two are obvioulsy related but they are distinct. And actually I said genes were simple which they are.




vincentML -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 10:10:20 AM)

quote:

ORIGINAL: meatcleaver

quote:

ORIGINAL: vincentML

Your reasoning is absolutist and ass backwards. Pure nonsense. Not all violent offenders are psychopathic and not all psychopaths are violent offenders, for example.

It is more logical to say that if a person is so tortured by a mental disorder that he becomes a spree killer it is reasonable to identify others with a similar mental disorder for treatment, and it is reasonable to seek a more efficacious regimen.



You have your head up your ass when you consider 30% of the population will suffer mental illness in their life time. Let me repeat 30% That many makes mental illness normal and mass murder is not normal so where is the correlation?

quote:

ORIGINAL: vincentML

Or the "error" may be due to Epistemic Uncertainty which includes limits of measurement, insufficient data, and the limits of bell curve probability to account for the Black Swan event.



You are obviously married to the idea that people who are mentally ill are mad bad and dangerous but most killers are clinically sane, even mass murderers so your hypothesis has a gaping hole in it to start with.


Firstly, mass murderers are clinically sane? WTF? How do you know that? Many committed suicide. Did they leave you a note proclaiming their clinical sanity?

Secondly, you once again have the premise ass backwards. Nowhere did I say the mentally ill are mad, bad and dangerous. I said the mass killers are mentally ill. Please try to keep straight the main premise. FFS!!

Let me show you what I mean by epistemic uncertainty ~ black swan events. And let's use your figure of 30% mentally ill. For the sake of this exercise we will assume equal distribution between males and females.

Here is a gallery of the top 20 US spree killers. One was younger than 14 and one was older than 50. For simplicity let's cut the age group off at 15 to 44, where most of them fall. Since they are all males we will use a figure of 15% incidence of mental illness. Half your number.

The US Census for 2010 recorded a population of males between ages 15 and 44 as 63,387,000.

15% of that male population is 9,508,050 individuals with mental illness. My presumption is that these 20 spree killers came from that population of 9.5 million, to leave out the calculus necessary to determine Census figures for each year a crime was committed.

What are the probabilities of those 20 spree killings happening? Do the math. It comes out to 0.00021%

Somewhat higher if we adjust the male populations for years of incidents, but not enough to show up on the Gaussian Curve of Normal Distribution except way the fuck out on the tail. What was your term? "statistical error." Statistical error, my ass! These were real events for which the bell curve could not account. You are using 19th Century probability statistics.

These events are highly improbable but highly impactful when they occur. Statistics fail. That is why genetic studies with vastly improving techniques are justified.





IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 4:15:30 PM)


quote:

ORIGINAL: DomKen

quote:

ORIGINAL: IgorsHand


However, you brought up epigenetics which illustrates that genetics is not simple which I think you claimed.

Epigenetics is not genetics. The two are obvioulsy related but they are distinct. And actually I said genes were simple which they are.


No they are not distinct, in fact there hasn't yet been a definition formulated to describe epigenics.

Genetics is simple like going to Mars is simple. Please use your brains, we aren't all stupid and easily fooled.




IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 4:19:51 PM)

quote:

ORIGINAL: vincentML

These events are highly improbable but highly impactful when they occur. Statistics fail. That is why genetic studies with vastly improving techniques are justified.




If statistics fail because of high improbabilty, you are by your own admission talking nonsense.

I'll leave it to someoe else to explain why because coming out with such nonsense shows you aren't worth spending the time educating.




DomKen -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 4:33:22 PM)

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

quote:

ORIGINAL: IgorsHand


However, you brought up epigenetics which illustrates that genetics is not simple which I think you claimed.

Epigenetics is not genetics. The two are obvioulsy related but they are distinct. And actually I said genes were simple which they are.


No they are not distinct, in fact there hasn't yet been a definition formulated to describe epigenics.

Genetics is simple like going to Mars is simple. Please use your brains, we aren't all stupid and easily fooled.

Epigenetics are heritable charicteristics independent of genes.

Genes are simple, they contain the information required to make proteins.

If you don't understand this then you are too ill informed to be involved in this discussion.




IgorsHand -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 4:38:38 PM)


quote:

ORIGINAL: DomKen

Epigenetics are heritable charicteristics independent of genes.

Genes are simple, they contain the information required to make proteins.

If you don't understand this then you are too ill informed to be involved in this discussion.


YAWN Why haven't you got a Nobel prize if genetics are so simple? Because you know and I know and everyone else knows they aren't that simple.

Epigenetics are not heritable characteristics independent of genes. Grow up.




PeonForHer -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 4:46:55 PM)

FR

No offence to all, but why are you bothering to discuss this? This research isn't going to go anywhere except into a hundred different kinds of fog. Its chief purpose is to channel thoughts and feelings into an emotional and intellectual miasma that'll never yield any answers that are of any real, practical use. The solutions to such random mass-killings are very plainly political and social, not psychological, psychiatric or neurological.




DomKen -> RE: Sorting Adam Lanza's Genome For Clues (1/5/2013 4:50:26 PM)

quote:

ORIGINAL: IgorsHand


quote:

ORIGINAL: DomKen

Epigenetics are heritable charicteristics independent of genes.

Genes are simple, they contain the information required to make proteins.

If you don't understand this then you are too ill informed to be involved in this discussion.


YAWN Why haven't you got a Nobel prize if genetics are so simple? Because you know and I know and everyone else knows they aren't that simple.

Epigenetics are not heritable characteristics independent of genes. Grow up.

There is no Nobel in genetics.

Genes are simple. The systems they produce are not so simple. That doesn't change the facts. Genes code for proteins. Figuring out how all those proteins interact is complicated.

Epigenetics are heritable characteristics independent of genes. Probably the most common form is the methylation of genes to turn off the production of that specific protein. The gene is unchanged.




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