Aswad -> RE: Anti sub drop? (4/20/2007 8:52:36 AM)
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ORIGINAL: darkinshadows One of the chemicals released during orgasm and sexual stimulation is prolactin. Prolactin is the hormone that stimulates lactation. The major effect of increased prolactin is a decrease in normal levels of sex hormones — estrogen in women and testosterone in men – and the effects of sudden changes to those two hormones are pretty wide known. quote:
Not entirely correct. Yes, prolactin reduces oestrogen synthesis in the ovaries. But oestrogen increases the prolactin release, so this system is in homeostatic balance. You won't throw it off a lot without noticing tons of other effects, like amenorrhea. The main effect of prolactin, in a mental health perspective, is decreasing testosterone in both genders. Remember that testosterone is not an exclusively male sex hormone, but also a very important one for women as well. Further, prolactin has a weak inhibiting effect on central dopamine levels. Also, AFAIK, prolactin is released during orgasm, not arousal. If it were released to any significant extent during arousal, you would be unable to achieve orgasm. I'd point at PEA (phenylethylamine) as a more likely culprit. Its levels are raised during arousal, and it works pretty much the same as amphetamine, but specific to the dopamine receptors, and with a halflife of 0.5-15 minutes, it gives the same come-down as amphetamines do. Selegiline/Emsam and unselective MAOIs extend this half-life quite significantly. A quick point about PEA is that it causes pupil dilation, so that might be a good non-invasive test. quote:
This can cause tiredness and bouts of depression. It represses dopamine which is important to the whole survival instinct. Ie - it fucks with the whole eat/sleep/reproduce/flight or fight responses causing confusion and depression or disinterest.quote:
Reduced dopamine levels will cause impaired motivation, emotional flatness, etc., and is involved in certain subtypes of depression, specifically those responsive to MAOIs, NARIs and DARIs. Eating and sleeping are mediated by other systems. Fight-or-flight is fairly exclusively mediated by norepinephrine. Confusion is a strong sign of excessive dopamine levels, while complete brain fog is a weak sign of low dopamine. Depression and disinterest, however, are correct. No idea about reproduction, though I expect it to be positively correlated with dopamine and oxytocin, as well as the ovulatory cycle. quote:
Its suggested that the sudden flooding of different hormones and chemicals can send the brain into confusion.quote:
Perhaps. Said confusion is usually called a "high", however, which only corresponds to the positive part of her experience, but that's another matter. Note also that our brains are meant for this kind of flooding. They just aren't meant to shut down so quickly. More relevant is the pulsatile stimulation of dopaminergic receptors, potentially causing adaptive changes. A partial agonist might solve that problem, but it's not a solution to the situation itself. quote:
In men, if they have high releases of prolactin, it can cause them to be subdued and back off (which Scooter may be doing - so it isnt always a 'blame the D-type' matter because he can't control the medical side in this instance) or even fall asleep immediately after orgasm.quote:
The main effect of prolactin on men is that it causes an orgasm refractory period, although the fatigue might be related. Even a short burst of prolactin will affect your testosterone, although most men won't see long-term changes from that. Overbalancing this system, however, can put it into negative feedback. That takes a lot, though. quote:
In a stable relationship that has had a routine, the dopamine adapts and learns when to ‘reward’ your own particular system - and if that doesn’t happen or suddenly changes it takes time for the release of the dopamine to react.quote:
Actually, stable relationships are more about oxytocin, which mediates trust and bonding. Dopamine fires whenever there are major changes in the neurohormonal balance or neurotransmitter activity, which focuses attention on the situation that caused it. An evolutionary adaptation for imprinting important situations. It has nothing to do with reward in itself, as it fires strongly during negative stimuli as well. Rather, it has to do with the impact and the learning of responses (habituation and motivation), etc. Firing speed doesn't usually change, IIRC, nor would it significantly matter, as clearly demonstrated by the myriad drugs that affect the time-domain of the impulse. quote:
So it means (in twice case on a hormone level) your body falls into a state of confusion – hence the whole up and down of sub space or drop. One minute you can be laughing, the next in tears – or in tears when you are laughing – or enjoying sensations or hating them. Because the body isn’t sure whether to reward or run away.quote:
What she is describing, is a sustained impact on her mood, and a withdrawal from her Dom. This is not consistent with sub drop. It's consistent with trauma. Sorry for such a long-winded explanation.
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