DarlingSavage -> RE: Why do we get all uppity about Weight based Threads? (3/24/2010 9:01:06 AM)
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I am wondering, DarlingSavage, where in my response do you see any kind of personal attack? I simply offered a differing point of view. Re: obesity being the cause of diabetes, studies in the last 3 years have suggested otherwise: http://www.sciencedaily.com/releases/2007/11/071106133106.htm Inflammation has a strong connection to heart disease and stroke as well. American Heart Association Also: http://www.clevelandclinic.org/heartcenter/pub/news/hot/inflammation8_02.asp?firstCat=1&secondCat=429&thirdCat=524 Since it has come up several times in this thread...the issue of why some people over-eat and others do not, is much more complicated than the simplistic idea that over-weight people simply lack will-power. Much of the cues for satiety are within our brain chemistry and for some people there are other less understood factors that create a mind/body disconnect which manifest themselves in someone eating when they are not hungry. From the very first paragraph in the article in ScienceDaily: Their discovery may pave the way to novel drug development to fight the epidemic of Type 2 diabetes associated with obesity, the most prevalent metabolic disease worldwide. Have you read this entire article? It states that: Macrophages, found in white blood cells in the bone marrow, are key players in the immune response. When these immune cells get into tissues, such as adipose (fat) or liver tissue, they release cytokines, which are chemical messenger molecules used by immune and nerve cells to communicate. These cytokines cause the neighboring liver, muscle or fat cells to become insulin resistant, which in turn can lead to Type 2 diabetes. It says right here that there is a series of events that occur which lead up to type 2 diabetes. The fat itself does not cause type 2 diabetes, however, it leads up to it. The only way that people aren't going to get type 2 through obesity is if they don't have any macrophage production. This is a study for a development of a new drug that will suppress macrophage production in obese people. The article quotes: "If we can block or disarm this macrophage inflammatory pathway in humans, we could interrupt the cascade that leads to insulin resistance and diabetes," said Olefsky. "A small molecule compound to block JNK1 could prove a potent insulin-sensitizing, anti-diabetic agent." The research also proved that obesity without inflammation does not result in insulin resistance. Olefsky explained that when an animal or a human being becomes obese, they develop steatosis, or increased fat in the liver. The steatosis leads to liver inflammation and hepatic insulin resistance. They conclude: "We aren't suggesting that obesity is healthy, but indications are promising that, by blocking the macrophage pathway, scientists may find a way to prevent the Type 2 diabetes now linked to obesity and fatty livers," Olefsky said. In other words, you won't get type 2 diabetes from obesity if you don't produce macrophages, if we can stop your body from doing what it normally does as a result of being obese, then we can stop you from getting this disease. But what will happen to the person if their body isn't able to function normally? Inflammation is your body's response to injury, it's your body's way of protecting itself from infection. This wouldn't be occuring if something else wasn't already wrong. That's what they'll have to look at next. They need to see what the long term results will be of stopping this process. This hasn't even been done with human beings, either. Mice were the test subjects. Furthermore, these aren't "studies" this is A study done 3 years ago. Subsequent studies done through this vein might totally disprove what these people have put forth. However, their proposal is to give people medicine to disrupt the macrophage pathway. Do you know what macrophages are? I'd like to address the other 2 articles but I can't do so at this time. However, from a very cursory glance, these articles in no way try to suggest that heart disease and stroke cannot be the result of poor lifestyle choices. These articles appear to merely be describing some of the series of events that occur leading up to heart disease and stroke. I'll be happy to look at these later, but for now, I have to go.
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